Why statin cause myopathy

The exact pathophysiology of statin-induced myopathy is not fully known. Multiple pathophysiological mechanisms may contribute to statin myotoxicity. Medically reviewed by Alan Carter, Pharm. Classifications of myopathy. Symptoms of statin-induced myopathy. Risk factors. Managing myopathy. Read this next. Medically reviewed by Aleah Rodriguez, PharmD. Can Statins Make You Tired? What to Know About Familial Hypertriglyceridemia. These direct myotoxic effects of statins are also referred to as " self-limiting " because symptoms tend to resolve either by lowering the dose, changing to a lower potency statin, or stopping the statin 2.

More recently, there have been reports of an immune-mediated necrotising myopathy associated with statin use. This autoimmune myopathy is characterised by progressive muscle weakness, elevated creatine kinase levels, and progression of signs and symptoms even when the statin is stopped 3.

A comparison of self-limiting muscle effects and immune-mediated necrotising myopathy associated with statins is provided in Table 1. Table 1: Comparison of self-limiting muscle effects and immune-mediated necrotising myopathy associated with statins 4.

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Cardiovasc Drugs Ther. For consumers. FDA: Limit use of 80 mg simvastatin. Updated June Accessed January 10, The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis. Curr Opin Lipidol. Risk factors and drug interactions predisposing to statin-induced myopathy.

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