My colleagues and I concluded that HLA-B27 could introduce a cognitive bias in making a diagnosis for patients with mild back pain. While we believe it is a step forward, only posterity will determine if it could be a step back. This research was supported by the Spondylitis Association of America.
Abbvie has provided funding to the Spondylitis Association of America in support of this survey, but it did not participate in the design of the survey, the interpretation of results, or the writing of manuscripts. Web services were donated by Any-3 London. This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.
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Findings from an SAA-sponsored Survey. Print Friendly. These tests can be used to ensure a suitable match between you and a donor. The HLA-B27 test involves a standard blood draw. They usually take the blood sample from your arm using a small needle. Your blood is collected in a tube and sent to a lab for analysis. Most of the time, no special preparation is necessary. However, talk to your doctor to see if you need to stop taking any of your medications before the blood draw.
Some people may experience discomfort when their blood is drawn. You may feel pain at the puncture site during the test and mild pain or throbbing at the puncture site afterward. When making a final diagnosis, your doctor will consider all test results along with your symptoms.
If the test is positive, this means that HLA-B27 is present in your blood. Diagnosis of an autoimmune disorder must be made based on your symptoms and the results of all blood tests and diagnostic exams. The HLA-B27 blood test is one step in the process of diagnosing a potential autoimmune disorder. Neither positive nor negative results to the test should be taken as confirmation of whether you have an autoimmune disorder or not.
Your doctor will talk to you about the next steps after you receive the results. You may have tests such as:. Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you.
A negative result means you don't have HLA-B27 in your blood. A positive result means HLA-B27 was found in your blood. You may have a higher-than-average risk of certain autoimmune diseases, such as ankylosing spondylitis and reactive arthritis. If you are white, you are more likely to test positive for the HLA-B27 antigens.
If you need an organ or tissue transplant and your HLA antigens are not compatible with those of your donor, your body could reject the transplant. The test is done with a blood sample. If you have AS and tests show you carry the HLA-B27 gene then there is a 1 in 2 chance that you could pass on the gene to any children you have. Page last reviewed: 11 July Next review due: 11 July Can ankylosing spondylitis be inherited?
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